Abstract
Summary
1. When the anterior pituitary glands of cattle are kept in vitro in cane sugar solutions or in glycerin, luteinization processes in theca and granulosa predominate; but if the glands are left in the solution for only one hour atresin effects may still be noticeable. Thyroid hypertrophy is found in the majority of cases. 2. When, instead of cane sugar or glycerin, solutions of urea are used, formation of mature follicles is induced by the glands thus treated in more than one-third of the cases. In another third the action of the urea was so strong that all the ovarian hormones were eliminated. In the majority of these animals also the thyroid hormone had been lost, but in some cases the formation of mature follicles was associated with thyroid hypertrophy. In somewhat less than one-third of the cases formation of pseudolutein bodies, with or without other luteinization processes, and in a few cases atresin effects were observable. 3. While thus glycerin and cane sugar solutions make possible the production of luteinizing effects by the implanted glands, after application of urea solutions only maturation processes are produced, or luteinization effects mainly of the granulosa, or in still other cases all the hormones are eliminated.
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