Abstract
Conclusions
Sensory anesthesia produced by 0.25 % concentration in normal salt solution on the frog's sciatic nerve has been tested on a considerable series by immersion of the toes in 1% HCl. The results obtained were: 1. The mean and median durations of anesthesia fall in the following ascending order: Procaine HCI, Meta-mine, Cocaine HCI, Panthesine. 2. A high degree of range is found for the 4 drugs studied. 3. The absolute variability in duration of anesthesia falls in the following ascending order : Procaine HCI, Metacaine, Cocaine HCl, Panthesine. 4. The relative varia-bility in duration falls in the following order: Panthesine, Metacaine, Cocaine HCI, Procaine HC1. 5. All distributions of duration of anesthesia show a distinct measure of skewness, those for Procaine HCl and Panthesine being positive and those for Cocaine HC1 and Metacaine being negative. 6. The differences in mean duration of anesthesia between the several drugs is highly significant in 4 pairings, probably significant in one, and doubtful in another.
Get full access to this article
View all access options for this article.