Abstract
Summary and Conclusions
1. Six out of 12 Rhesus monkeys failed to secrete free acid in their gastric juice 45 to 60 minutes after subcutaneous injections of 0.5 mg. histamine while 5 out of 12 failed to respond to 1.0 cc. of a preparation of “gastrin”. 2. Three out of 12 monkeys were refractory to 1.0 mg. of histamine and to 2.0 cc. of the “gastrin”preparation. 3. The “gastrin extracts”of hog's pyloric mucosa did not contain a substance capable of stimu-lating acid gastric secretion other than histamine, both in the normal and anacid monkeys. 4. None of the 12 monkeys secreted free acid in the gastric juice in response to 7% alcohol or to a meal of farina gruel and boiled potatoes.
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