Abstract
Conclusion
The effects of prolonged daily administration of estrogenic substance to normal and to castrated adult female rats are compared. It is concluded that, in the rat, “estrin’ alone can not completely replace the ovary in the induction of the uterine changes of the estrus phenomenon. Our results indicate the existence of ovarian factors other than estrin (or progestin) which influence the estrus phenomenon in at least 3 respects: 1. Preliminary inhibition of the uterine response to estrin. 2. Rhythmic activity of the endometrium. 3. Aubmentation of the uterine response to estrin.
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