Abstract
Conclusions
In thyroidectomized young guinea pigs anterior pituitary extract of cattle exerts its growth-promoting effect on the cartilage of the joint as well as in non-thyroidectomized animals, and the same arthropathic changes characteristic of acromegaly develop in both. Lack of the thyroid gland does not only not prevent the growth-promoting effect of anterior pituitary extracts, but in thyroidectomized guinea pigs the phenomena are even more pronounced than in normal animals which were treated with the extract. These experiments provide, therefore, further evidence for the conclusion that the extract exerts its influence on bone, epiphyseal line and joint cartilage without the intermediation of the thyroid gland.
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