Abstract
Conclusions
The long-continued injection of acid anterior pituitary extracts and acid extracts of human pregnancy blood produced markedly different growth effects in the female albino rat breast. The acid pituitary extract response was characterized by growth and proliferation of the duct system with increasing periductile fibrosis and the appearance of fibroadenomatous areas, but without alveolar or lobule growth proliferation. In response to extracts of human pregnancy blood there was an unfolding, growth and hyperplasia of the alveolar mammary tree with secretion changes, milk production, and after long continued injections, regressive changes, often accompanied by the appearance of adenomatous tumors of the breast.
Get full access to this article
View all access options for this article.