Abstract
Summary
Subcutaneous administration of dinitrophend in varying amounts from 10 nig. to 24 mg./k., over a period of 37 days, had no apparent effect on the production of agglutinins for B. pnmfgpltoszu I3 in rahbits. Large amounts, 30 to 40 mg. per kilo, sufficient to increase the temperature several degrees, did not significantly alter the agglutinin-titers. Similar large doses given after a rest period of from 4 to 11 months failed to cause a secondary rise in titer except in one instance. A very slight decrease in complement-content took place in 2 of 3 experiments following large doses of dinitrophenol. The above results did not encourage more extensive investigation.
Get full access to this article
View all access options for this article.