Abstract
Conclusion
In young guinea pigs, under the influence of acid extract of cattle anterior pituitary, the growth-promoting effect manifests itself as acromegalic arthropathia in 2 directions: (1) Hypertrophy and hyperplasia starting in the transitional zone of cartilage then proceeding towards its sliding and pressure zone, and in a later stage leading to its liquefaction and to ulceration of the surface. (2) This stimulation of the growth of cartilage may be followed by calcification. In the latter case the ulcerative processes are less pronounced than in the former. Whether the one or the other of these 2 effects occurs does not depend upon the number of injections given to the animals.
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