Influence of Glycine on Depleted Creatine Reserves of Skeletal and Cardiac Muscle in Experimental Hyperthyroidism. ∗

Abstract

Conclusion

The results of these experiments offer no evidence of the conversion of glycine into creatine. That this amino acid is not a precursor of creatine is indicated by some of the data, but admittedly more conclusive evidence is needed to establish this view. Difficulty in the interpretation of the results is due partly to the fact that the fate of creatine is not limited to storage, excretion, and conversion into creatinine. A large part is used up in other ways. Moreover, in hyperthyroidism, as in certain muscle diseases, 1 the capacity of muscle to take up and retain creatine is deficient, even though the concentration may be considerably below normal.