Abstract
This report is based on 17 adult or subadult Rhesus monkeys which were hypophysectomized at varying stages in the sex cycle and have post-operative periods varying from 4 to 111 days. Eighteen 10-day periods of injection with oestrin (Progynon B, dihydrotheelin, Amniotin) were given and in 3 cases this was followed by progestin for 10 days (1 or 2 Rab. U./day).† Fourteen of these animals have been autopsied and the completeness of the ablation verified by a study of serial sections of the hypophyseal capsule.
The hypophysectomies were performed by the oral approach. The soft palate was incised and the hypophysis exposed by an opening through the sphenoid. The exposure of the gland with this approach is excellent, a clear view of all but the most lateral parts of the gland being secured. The penetration of the pituitary stalk through the diaphragma is clearly seen. The pars tuberalis is not removed. It is quite extensive in the monkey. The incidence of infection is low, 2 animals out of approximately 30 operated on having developed serious infection at the site of operation.
Hypophysectomy during menstruation did not prolong bleeding nor did it induce bleeding if done shortly after menstruation. Animals hypophysectomized in the middle of the cycle and showing a well developed sex-skin color showed on 2nd to the 4th day thereafter grossly evident uterine bleeding which lasted for 3 to 6 days. Bleeding was prevented by the injection of oestrin (400-500) R.U./day was given). If untreated the endometrium and the vaginal epithelium showed an involution as great or greater than after castration.
Get full access to this article
View all access options for this article.