Abstract
It has been shown by Van Wagoner and Churchill 1 and Barbour and Fisk 2 that relatively large doses of cincophen administered daily by stomach tube will cause gastro-duodenal ulcer and liver damage. The occurrence of ulcer after cincophen administration has recently been reported to occur in man. 3 It has also been found that gastric mucin is prophylactic against the gastro-duodenal ulcer and disturbance of nutrition that results in some biliary fistula dogs 4 and is of benefit in the nutritional disturbance that occurs in some Eck fistula (liver damage) dogs. 5 Accordingly, we decided to ascertain if gastric mucin might prevent the occurrence of “peptic” ulcer in and prolong the life of dogs receiving large doses of cincophen.
Twenty-eight healthy dogs were used. Fifteen served as controls in that they received only cincophen, and 13 received both cincophen and mucin. The cincophen was made up in a starch paste solution (20 gm. of cincophen, 40 gm. starch and 2000 cc. H2O), and administered by stomach tube to all dogs once daily in a dose of 100 mg. per kilo. The dogs that were given mucin received 30 gm. in solution in water about 2 hours before the cincophen in the morning and a second dose of 30 gm. during the evening. The dogs were given the regular stock diet consisting of yellow corn meal, bone soup, ground meat and baker's bread. The treatment was continued in the control group until they died, and in the group treated with much until they died or the experiment was terminated at 60 or 80 days. Portions of the liver and kidneys were removed for histologic study.
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