Abstract
It has previously been reported 1 that the sex skin reactions of rhesus macaques, which can be called forth by injection of oestriol, eventually spread over a wide extra-genital area if the injections of this hormone are continued for longer than a month. Minor degrees of this extra-genital oedema can be observed in many untreated cyclic females at certain periods of the year, but the full manifestations possible after prolonged oestriol treatment have not been observed to date in a considerable experience with untreated macaques. In the further study of these phenomena, it was of interest to see whether the results obtained with oestriol could be duplicated with oestrone. Also, in view of the symmetrical character of the sex skin reactions, it was felt desirable to investigate a few relationships of the segmental nerve supply of the affected areas to the reactions occurring therein.
Females only were used. Two adult castrates, one adolescent castrate, and 2 adolescent but acyclic intact animals were injected subcutaneously once daily for 48, 48, 74, 74 and 76 days respectively with 500 y of crystalline-folliculine (Girard) dissolved in corn oil.
A typical experiment will show that the responses previously elicited by oestriol were duplicated by the use of oestrone. Monkey No. 885, a 4275 gm. female castrate, had been used during the original experiments with oestriol, but had received no treatment for 7 months.
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