Abstract
Zifferblatt and Seelaus 1 have reported successful desensitization of guinea pigs by repeated intraperitoneal injection of an aqueous solution of iodine. This report would appear to lend support to the belief long held by many clinicians that in some asthmatics continued iodide administration rendered their attacks less frequent and severe. It, therefore, seemed worth while to see if iodide therapy in sensitized guinea pigs would also result in desensitization. The negative results obtained are stated in Table I.
All pigs received a subcutaneous injection of 1/20 ccm. of dog serum January 11.
All pigs were autopsied and in those dying after the intravenous injections, the lungs showed typical distension.
Although the series is small the results are so negative that it may be concluded that iodide administration does not desensitize sensitized guinea pigs.
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