Abstract
Summary
In 14 menopause cases in which a hyperexcretion of gonadotropic factor was observed, injection of 4,000 to 22,000 R.U. of estrogenic factor was followed by a rapid decrease of gonadotropic factor in the blood and urine. The disappearance of the prepituitary hormone persisted for from 28 to 70 days but was regularly followed by a return to the condition noted before treatment. The amelioration of subjective symptoms roughly paralleled the decrease of the gonadotropic factor in the urine.
From these studies it appears that the hypophyseal hyperactivity which follows castration or appears in the spontaneous menopause (Zondek, 4 Fluhman 5 ) can be temporarily ameliorated by the administration of estrogenic factor in high dosage.
Graph of a typical case is appended.
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