Abstract
Conclusion
The above results confirm for phenobarbital those reported by Loewe for barbital. It is apparent that when an analgesic is given simultaneously with a hypnotic drug, care must be exercised in the choice of the former. Thus, whereas acetyl salicylic acid antagonizes the hypnotic action of phenobarbital, phenacetin in no way diminishes its activity. Furthermore, the evidence shows that phenacetin may exert a protective influence by antagonizing the toxic effects of phenobarbital.
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