Abstract
Churchill and Van Wagoner 1 demonstrated that gastric and duodenal ulcers can be regularly produced in dogs by administration of cincophen. Cases of alleged cincophen poisoning in man have not been characterized by such ulcers. It appeared desirable, therefore, to determine whether this effect in the dog is a species-selective phenomenon.
Cats, rabbits and guinea pigs were given cincophen orally suspended in cotton seed oil. The dosages were calculated according to the principle used by Churchill and Van Wagoner, i. e., on the basis of 22 mg. per kg. body weight which corresponds to the human dose of 7.5 grains t.i.d. for the average adult of 150 lbs. During the experiment the animals received the usual care given to the particular type of experimental animal. In each case the postmortem examination was done as soon after death as possible.
The following tables give a resumé of the results.
Results with Cats
Cat No. 1. 2 doses each 10x N.H.D.∗ Death on second day. A few superficial erosions in gastric mucosa up to 4 mm. in diameter.
Cat No. 2. 4 doses each 10x N.H.D. Death on 5th day. Numerous erosions and one ulcer 1.5 cm. in diameter, chiefly in the fundus of the stomach.
Cat No. 3. 12 doses each 5x N.H.D. Death on 14th day. Two superficial ulcers 4 and 7 mm. respectively, on lesser curvature near pylorus.
Cat No. 4. 17 doses each 2 1/2x N.H.D. Death on 17th day. No ulcers in stomach.
Cat No. 5. 47 doses each 1x N.H.D. Death from peritonitis on 54th day. Perforating ulcer 3×10 mm. near the cardia. Several superficial ulcers up to 4 mm. on lesser curvature.
Cat No. 6. 62 doses 1× N.H.D. Death on 67th day. No ulcer. Large intestine contained several superficial ulcers and was edematous and hyperemic.
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