Abstract
Twenty-eight commercial antistreptococcus serums† have been titrated for their neutralizing power (a) against the specific antihuman streptococcus fibrinolysin of Tillett and Garner, 1 and (b) against the two antiveterinary streptofibrinolysins of Madison. 2 The highest serial dilution of each antiserum completely neutralizing an arbitrary fibrinolytic dose of the selected streptococcus filtrates was taken as its approximate titer. Data thus obtained are recorded in Table I.
The table shows that each of 3 animal species tested is relatively immune to the homologous streptofibrinolysin, but has only minimum humoral defenses against the 2 heterologous streptolysins.
The titers of the specific antiserums suggest that only 6 (21%) of the 28 serums tested are of sufficiently high antifibrinolytic conment to serve as effective passive antifibrinolytic immunizing agents i. g. man.‡ But 2 (7%) of them would be similarly effective with horses. None of the antiserums would have a predictable antifibrinolytic immunizing value for domestic swine.
It is of interest that the 7 “refined” and “concentrated” antiserums in the above list are not appreciably superior to the 21 presumably untreated antiserums.
Get full access to this article
View all access options for this article.