Abstract
Summary
1. Twenty patients were given repeated spinal punctures after ingesting varying amounts of bromide. 2. A state of equilibrium between the bromide of the blood and that of the cere-brospinal fluid is maintained from the end of the 5-day bromide in-gestion period to the ninth day. 3. The permeability quotient tends to rise with the passage of time indicating that after the drug has been discontinued the return of bromide from the cerebrospinal fluid to the blood is relatively more rapid than the elimination of bromide from the blood. 4. Permeability quotients do not vary widely when the bromide concentration of the blood is high; significant variations are detected when the bromide content of the blood is maintained between 50 and 150 mg. per 100 cc. 5. The method employed is practicable and provides an ideal concentration of bromide in the blood.
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