Abstract
Summary
A solution of undenatured H. pertussis protein was found to be oxytocic in the Dale bath in high dilution. The normal guinea pig uterus reacted with a histamine-like contraction to repeated additions of H. pertussis protein-1 part in 100,000.
Active sensitization of the guinea pig uterus to undenatured H. pertussis protein was produced hy repeated intraperitoneal injections of Jiving Phase 1 H. pertussis. In one instance the classical Schultz-Dale reaction was obtained with 1 part of H. pertussis protein in 7,200,000. The uterine strips of 3 other animals prepared by injection of living H. pertussis contracted and were desensitized in dilution only slightly higher than oxytocic.
Active sensitization of the guinea pig uterus was also produced in one instance by a single subcutaneous injection of undenatured H. pertussis protein. The strip contracted and was desensitized by 1 part of H. pertussis protein in 720,000. Passive sensitization with H. pertussis immune sera of high titer was unsuccessful.
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