Abstract
Summary
The glycolytic enzyme of muscle extract after becoming inactive on standing can be reactivated by thioglycolic acid to a higher state of activity than that originally present. Lipmann's hypothesis of the enzyme being inactivated by oxidation and reactivated by reduction is corroborated and specified by the evidence that this oxidation-reduction is concerned with a sulphydril group of the enzyme. There is evidence for the assumption that glycolytic enzyme of muscle seems to be a sulphydril compound which loses its enzymatic property by oxidation to the disulphide state and is reactivated by reduction to the sulphydril state.
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