Abstract
Summary
At a given initial fiber length the mechanical energy of contraction of the heart is increased under the influence of calcium. This is due not only to an increase in the fraction of the total energy liberated which is converted into useful work but also to an increased total energy liberation. The increase in efficiency occurring with administration of small doses of calcium salts indicates that the effect is a beneficial one, and might be of importance in contributing to the therapeutic effect of calcium in cardiac disease.
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