Abstract
Summary
Twenty-eight female rats were fed amounts of desiccated thyroid ranging from 250 to 1,000 mg. daily. The oestral cycle was suppressed to varying degrees, dependent on the dosage of thyroid. The pituitaries were subnormal in weight. Histologically the anterior lobes exhibited certain changes : most notable was a slight increase in the percentage of the basophiles and a definite increase in the size and granular content of these cells. The granules stained a purple-red which varied to a dull brick-red; in normal female rats (virgin and killed during the normal oestral cycle) the basophiles take a deep blue stain. The changes in the basophiles were most marked in those animals in which the suppression of the oestral cycle n-as most evident.
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