Abstract
Our experiments were designed to ascertain the effects of the sulphates of sodium and magnesium on the gastro-intestinal tract of unanesthetized dogs, each having a gastric and intestinal fistula. Rozen and Perussé 1 using unanesthetized dogs with a gastric fistula reported on gastric activity several hours after the use of magnesium chloride but other similar work has not been noted.
Two female dogs, S and B, were used as subjects. The fistulae were made after the manner of Thiry 2 (intestinal) and Carlson 3 (gastric) in a 2 stage operation. The animals were in good physical condition. Food was withheld for 18 hours prior to an experiment, but water was allowed ad libitum. Both subjects were trained to lie quietly during the experiments. Our experiments will be described under 2 series since the technic in each differed.
Series I—This series deals with the effects of the sulphates of sodium and magnesium on gastro-intestinal activity when the salines were placed in the stomach, graphic records (smoked paper) being obtained from both stomach and intestinal segment by means of balloons and soap water manometers. The salines were usually given after a normal record of about 1 hour had been procured.
The controls for this series were of 2 kinds: (a) with the stomach empty and (b) with the stomach containing 0.85% sodium chloride.
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