Abstract
Summary
1. Rabbits have been successfully vaccinated by 5 subcutaneous injections of a heat-killed aqueous suspension of Type I pneumococcus vaccine against fatal intradermal pneumococcus infection. 2. When the vaccine was given by stomach tube about 38% of rabbits survived. 3. With Type II vaccine all animals including the controls survived following intradermal pneumococcus infection but the local lesions, septicemia and associated febrile and leukocytic changes were less marked among the immunized animals and especially those receiving 5 subcutaneous injections of vaccine. 4. All rabbits immunized with Type III vaccine by subcutaneous and oral administration survived along with 1 out of 2 controls following intradermal infection. The local lesions and associated fever and leukocytosis were milder among the vaccinated animals than in the controls and especially among those immunized with subcutaneous injections of vaccine.
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