Abstract
Dextrose and phosphates have a high tendency to react. They are both present in animal and human tissue as well as in the blood serum. When mixed in an aqueous solution in the same quantities, which are present in the blood serum, i. e., 3 mg. of P in the form of a neutral phosphate and ca. 100 mg. of dextrose per 100 cc, we find a very slight reaction, which can be assumed because we recover a little less of dextrose and a little less of phosphorus than we do when the chemicals are added separately; 2.8 mg. of P are recovered instead of 3 mg. per 100 cc, and 90 mg. of sugar instead of 100 mg. The same quantities added to human serum of a healthy individual react much more intensely. Instead of the original quantities added we recover only 25-50% of dextrose and ca. 70% of phosphorus. The loss of dextrose has been explained in the previous paper. It is caused by the increase of dextrose, which is counteracted by the serum colloids. The loss of phosphorus, however, does not occur if no sugar is added. In this case we recover 100% of the added phosphate. Urea added to the serum does not influence the serum phosphate, and also does not influence the dynamic equilibrium of the phosphate, when this salt (3 mg. per 100 cc.) and at the same time urea (30 mg. per 100 cc.) are added. We still recover the entire phosphate. The reaction between dextrose and phosphate, however, is intensely accelerated and intensified, if phosphate, urea and dextrose are added to the serum. In this case only a small quantity of the phosphate, 10%, and frequently none of the added salt can be recovered, provided the serum is that of a normal healthy individual.
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