Abstract
Summary
The antipyretic action of glucono-phenetidin in equimolecular proportions is about equal to the action of acetphenetidin when tested on rabbits fevered with injections of hay infusion. Glucono-phenetidin is non-toxic to rats in doses up to 50 gm. per kg., whereas acetphenetidin manifests occasional toxic symptoms in doses as low as 4 gm. per kg., and was fatal in 3 out of 5 animals with a dose of 6 gm. per kg. This indicates a definitely wider range between therapeutic and toxic dose for glucono-phenetidin than for acetphenetidin.
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