Abstract
Following the isolation of histamine from the pyloric mucosa, 1 it was suggested that histamine might be found in the blood stream after the ingestion of a meat meal. The extraction of quantities of blood for histamine by various methods gave a substance which possessed vasodepressor properties and gave a positive Pauly reaction but was uniformly negative (subcutaneous) in producing a gastric response.
Adenylic acid is one of the vasodepressor substances found in the blood stream. 2 According to Bennet and Drury, 3 3 mg. of adenylic acid intravenously cause a blood pressure fall of 40 mg. of mercury. Believing that this substance might be capable of producing a gastric secretory response, doses from 1.0 to 10.0 mg. were injected subcutaneously into Pavlov pouch dogs. The gastric response was uniformly negative.
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