Abstract
That barbiturates as well as other non-volative anesthetics (hypnotics) act additively with ethylene or nitrous oxide has been conclusively shown by several investigators as also by clinical experience. That this also holds good with ether seemed to have been shown by clinical observations. Consequently considerable surprise and doubt arose when Calderone5 reported that in dogs he had been unable to find any evidence that there was any additive effect of barbiturates when given with ether. This communication brings a brief report of the results obtained by us in further investigations of this problem.
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