Effect of Tyrosine on Botulinum Toxin

Abstract

Summary

We have failed to protect mice against small amounts of botulinum toxin by the injection of tyrosine and have not been able to confirm the work of Kempner and Schepilewsky. We feel that the suggestive results of 2 of our experiments on the effect of excess quantities of tyrosine on the formation of botulinum toxin are not significant in the light of the other experiments described here. We have also found that neither tyrosine nor phenylalanine had a deleterious effect on formed toxin when mixtures of the amino-acids and the toxic material were incubated together.