Experimental Jejunal Ulcer

Abstract

Conclusions

1. In a total series of 47 animals, the duodenal drainage operation of Mann and Williamson resulted in jejunal ulcer formation in 38 instances, 70.2%. 2. The incidence of death from peritonitis secondary to perforation was 34%. 3. There was no relationship between the site of drainage, i. e., whether high or low in the intestine, and the incidence or rapidity of ulcer formation. 4. Traumatic lesions of the jejunum healed promptly in spite of the formation of new ulcers in adjacent areas. 5. The experimental ulcers under consideration are not due to operative trauma, or merely to the chemical digestive action of the gastric juice, or to the two together. It is quite possible, however, that the continued mechanical and chemical trauma inflicted on the cells of the jejunal mucosa by the ejected acid chyme may be entirely responsible for the formation of the lesions.