Relationship Between Liver Injury Induced by Alcohol and Elimination of Phenolsulphonephthalein. 20

Abstract

Conclusions

1. The foregoing observations of the changes which develop in the liver in those animals which show an increase in the elimination of phenolsulphonephthalein in the urine from the use of alcohol when contrasted with animals which do not show these changes, would indicate that the liver injury is responsible for the increased output of the dye by the kidney either by decreasing the excretion of the dye by the liver into the intestine with its reabsorption and elimination by the kidney (Rowntree and Geraghty 2 ), or by decreasing the ability of the liver to destroy it (Kendall 5 ). These results obtained from the use of alcohol in 7 of 23 dogs, coincide with the observation of Hanner and Whipple 4 on the relationship which exists between a liver necrosis induced by chloroform and an increase in the elimination of phenolsulphonephthalein.

2. In this series of animals which developed a liver injury from alcohol with an increase in phenolsulphoneplthalein elimination the observation was made, that if the use of alcohol was withheld from 48 to 72 hours the elimilation of the dye underwent a reduction. An investigation of the liver changes which may develop in connection with the decrease in the output of this dye is now in progress.