Sclerosing Substances. Effect on Vascular Endothelium

Abstract

Conclusions

Whereas the destruction of endothelium is responsible for the development of sterile thrombi following injection of cclerosing substances, the extent of the destruction does not necessarily indicate the degree of thrombosis. In spite of extensive destruction of endothelium, coagulation occurs relatively infrequently, hut usually between the fourth and sixth days a regeneration of the endothelium occurs so that the vessel again becomes lined with a normal endothelium. This and the fact that canalization invariably occurs in the artificially produced thrombi possibly account for recurrences following the injection treatment of varicose veins.