On the Local Inhibition of the Shwartzman Phenomenon

Abstract

Summary

A number of experiments are described which demonstrate that local inhibition of the Shwartzman phenomenon can be achieved by treating the prepared skin area with a variety of substances immediately prior to the intravenous injection of reacting factors or by clamping off a portion of the prepared skin area for one hour after the intravenous injection. It is believed that these agents produce their effects by creating a local ischemia which shields the prepared skin tissue from the injurious agents circulating in the blood stream.