Abstract
Dawson and Sia 1 , 2 described a method for inducing transformation of pneumococcal types by an in vitro technique. In this procedure the transformation of pneumococci from one specific S type into other specific S types was effected through the intermediate stage of the R form. The method consisted in growing small inocula of R forms, derived from S forms of one specific type, in media containing vaccines prepared from cultures of heterologous S types.
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