Interrelation Between Secretion and Incretion.

Abstract

All attempts of different investigators to find out the interrelation between the external and internal secretion of the pancreatic gland have not been successful because the methods used, evaluation of blood sugar in the peripheral blood, 1 , 2 , 3 or acute pancreatico jugular transfusion experiments on anesthetized dogs 4 lack the conclusiveness of direct physiological research under natural conditions.

We used angiostomized dogs with pancreaticoduodenal and ad-renolumbal canulas. We know the secretion curves of pancreatic juice of the dog after feeding with proteins, carbohydrates and fats. 5 We built up curves of insulin and adrenalin incretion during digestion of the same species of food.

Comparison of the curves of external and internal pancreatic secretion shows no parallelism.

After feeding with cream, which is usually followed by abundant secretion of pancreatic juice, no insulin incretion at all could be detected. After feeding with meat, after which, during the first hours, a rapid rise of external pancreatic secretion is always observed, not until the fifth hour of digestion did some internal secretion begin, lasting a short while. It is only after feeding with bread that one could find some relation between secretion and incretion of the pancreas both being represented with high curves, though there is no real similarity between them.

High curves of insulin incretion are in this case the result of abundant secretion of pancreatic juice, only because of consecutive abundant sugar formation and absorption, increasing the blood sugar level, and through it the internal pancreatic secretion. It is not a case where excretion and incretion are the result of the same stimulating agent; incretion follows another stimulating agent which is the result of the action of the external factor on the carbohydrates of the food.