Abstract
Chiniofon, N. N. R., introduced commercially as “yatren”, and first tried clinically in amebiasis by Mühlens and Menk 1 in 1921, has had some popularity as an amebicidal agent. Chemically chiniofon is sodium-iodoxy-quinoline-sulphonate, and is related to chinosol N. N. R. (oxyquinoline sulphate) and vioform N. N. R. (iodo-chloroxyquinoline). Since chiniofon has been claimed to have amebicidal activity, we thought it might be of interest to study it from this standpoint in comparison with as many related compounds as we could secure. Such an effort we thought might yield significant information regarding the relation of chemical constitution to pharmacological action in this series of oxyquinoline derivatives, particularly with reference to the effects on biological activity of introducing various halogens into the oxyquinoline molecule.
We secured the following compounds for this investigation: 1. Oxyquinoline, from Dr. J. V. Barrow. 2. Oxyquinoline sulphate (Chinosol, N. N. R.). 3. Chloroxyquinoline, from the Ciba Co., Inc. 4. Sodium-iodoxyquinoline sulphonate (Chiniofon, N. N. R.). 5. Iodochloroxyquinoline (Vioform—Ciba, N. N. R.). 6. Diethylamino-dimethylene-hydroxy-iodochlorquinoline HCl, from the Ciba Co., Inc.
In this series, compounds 3 and 4 are monohalogenated derivatives of oxyquinoline, while in compounds 5 and 6, two different halogen atoms have been placed in the oxyquinoline molecules.
These substances have been studied with respect to toxicity on oral administration to guinea-pigs, rabbits, and cats; balanticidal action in naturally infested guinea pigs; amebicidal action in vitro, and therapeutic effect in monkeys naturally infested with intestinal parasites. The techniques followed have been previously described. 2 A general summary of part of this study appears in Table I.
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