Abstract
The influence of various concentrations of bile upon the gastric secretion in dogs with non-leaking fistulous openings in the stomach has been reported. 1 Some phases of the problem of antigenic absorption through an intact body surface covering layer have been reported, 2 and further work is in progress. This report deals with use of egg white as a vehicle to introduce an antigenic substance into the lumen of the small intestine. Bile has been used by Besredka 3 to sensitize or prepare the intestinal mucosa for antigenic absorption in his oral vaccination against the enteric group of infectious diseases. Arnold 4 offered a different explanation for the action of bile than that suggested by Besredka. Bateman 5 received the literature upon the digestibility and utilization of egg white in dogs and man. Raw egg white leaves the stomach more rapidly than other foods. Bateman showed that diarrhea followed the ingestion of certain amount of raw egg white. Arnold 4 showed that raw egg white injected into the duodenum of dogs caused increased permeability of the wall for bacteria.
Four dogs with non-leaking gastric fisulae were used for these experiments. The material placed into the gastric lumen through the fistulous opening was raw egg white (25 cc.). raw egg white (25 cc.) suspended in 200 cc. of distilled water and a mixture of raw egg white (25 cc.) desiccated ox bile (Difco 1 gm) suspended in 100 cc. of distilled water. The accompanying graph gives the average gastric acid secreting response to these substances. Stomach contents (1 or 2 cc.) were removed at half hour intervals and titrated in the usual manner.
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