Abstract
Rabbits were given tyramine subcutaneously in single doses of various sizes, in hourly doses and in daily doses. With but few exceptions the effect was to increase the number of red corpuscles per cubic millimeter in the circulating blood. The hydrochloride was used. This was dissolved in 0.9% sodium chloride solution in such proportion that 1 cc. contained the dose per kilo of body weight, and the solution warmed to body temperature before injection.
Single doses of from 0.1 mgm. to 20.0 mgm. per kilo of body weight were used. The average results of these are given in Table 1. A dose of 0.5 mgm. per kilo caused an increase in the red blood corpuscle count of 18.46% and was selected as an average effective dose.
Each of 4 rabbits was given 0.5 mgm. per kilo of body weight and the dose repeated at intervals of one hour until 4 doses had been given. The results are summarized in Table II.
Twelve rabbits, 15 weeks old, were divided into 3 groups of 4 each. Two groups received tyramine and the third served as a control. The tyramine was given daily for 2 weeks, then 3 times a week for 2 weeks, then daily for 2 weeks, and finally 3 times a week for 2 weeks. The dose for one group was 0.5 mgm. of the hydrochloride per kilo of body weight and for the other 5.0 mgm. per kilo. At the same time the control rabbits were given a subcutaneous injection of an equal quantity of 0.9% sodium chloride solution. Living conditions were the same for all. The red corpuscles were counted twice each week and the body weight was noted once a week.
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