Abstract
Intravenously injected horse proteins are retained quantitatively in the normal canine circulation for at least 4 days, by which time they are so far denatured as to call forth no recognizable anaphylactic reaction on massive blood transfusion into horse-protein-hypersensitive recipients. 1
No anaphylactic denaturization is demonstrable at the end of 4 days in endothelial blockaded (India ink) dogs. Approximately half of the routine protein dose remains anaphylactically active as late as the ninth day in these animals, and about an eighth as late as the fourteenth day.
This paper summarizes the results from 20 transfusion tests. The technique has been previously described. 1
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