Abstract
Eight normal, 13 phlorizinized, and 9 depancreatized dogs under amytal anesthesia were studied during rest and exercise. Blood entering and leaving muscle and liver was analyzed for fat, using the method of Stewart and White. 1 The experimental error was ±20 mg. %, and differences of 40 mg. % or more were considered significant. The differences of the arterial and venous fat contents of the blood of the muscles of the normal post-absorptive dogs varied, since the muscles liberated fat 5 times and removed it on 3 occasions. Of greater interest are the observations of the diabetic dogs, since in 10 of 13 significant determinations on the phlorizinized dogs, and 12 or 15 on the depancreatized animals, the muscles of the lower extremities removed fat from the blood passing through them.
The results obtained on the blood of the liver were not the same in the phlorizinized and depancreatized dogs. The livers of the phlorizinized dogs usually removed fat from the blood, while those of the depancreatized dogs added fat.
Thus these results obtained by the method of Stewart and White 2 indicate the utilization of the fat of the blood by the muscles of diabetic dogs.
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