Abstract
We have investigated the effect of various depressants of the oxygen consumption of excised kidney tissue of the rat in the Warburg apparatus.
Table I gives the oxygen consumption and the respiratory quotients, and Table II the calculated effect on carbohydrate and fat using the Zuntz-Schumburg-Lusk table.
With the depression of oxygen consumption there was an elevation of quotient in 9 out of 11 observations. Analysis of these data indicates that the oxidation of fat is interfered with more than that of carbohydrate. This is in contrast to the situation in diabetes where the primary injury is to the oxidation of carbohydrate.
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