Abstract
Summary
1. Small amounts of ephedrine in normal Ringer either increase cardiac activity moderately or are without effect, but a concentration of 1-5,000 always depresses the heart.
2. The depression produced by ephedrine is antagonized by adding stifficient amounts of calcium and aided by reducing the calcium content to about 50%. In still smaller amounts of calcium elphedrine is inactive.
3. Ephedrine stimulates the heart when both ions are omitted.
4. Ephedrine in excess potassium depresses the heart but this is TT iuch less than in deficient calcium.
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