Abstract
Within 6 days, the mammary tree of 24 day old female rats is clearly increased in complexity by all methods of administration of the anterior hypophyseal hormone known to us. We have employed bovine and rat implants and folliculin-free and growth hormone-free extracts of the ripe human placenta and of the urine of pregnant women. The implant method shows such an effect with only 2 daily treatments and sacrifice on the fourth day. In some cases hyperplasia was seen to have begun before lutein structures were present in the young ovaries. The secretion of corpora lutea therefore could not have been responsible for this stimulus to mammary growth, though the growth was always most marked in cases in which corpora lutea were coincident with a hypertrophied follicular apparatus.
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