Addiction Edema and Withdrawal Edema in Morphinized Rats.

Abstract

Conclusion

Morphinism in rats causes edema which tends to advance and decline at different rates in different tissues. Early and extensively affected is the skin. The water exchange becomes decidedly increased. Sudden withdrawal induces a fresh edema, especially of the brain, the skin passing first through a dry stage. The water exchange is first depressed, then greatly increased. Ingestion of food has not varied sufficiently in amount to account for any of the findings.