Abstract
A series of adrenalectomized rats was given subcutaneously 1 cc. of 1:50,000 adrenalin chloride (Parke Davis & Company) daily for periods of 7 days to 14 weeks. The animals were then urethanized and a fatigue curve of a gastrocnemius muscle obtained by a modification of the Gans and Miley method. 1
The results are shown in Table I.
The amount of work per gm. of muscle done in our series varied between 151 and 262,380 gm. cm., while with the adrenalectomized rats of Gans and Miley it varied between 1200 and 206,400 gm. cm. The average work per gm. of muscle of our rats amounted to 60,694 gm. cm., which is slightly less than that of their adrenalectomized rats—64,200 and only one-sixteenth of the average of their controls—1,015,300 gm. cm.
There is no evidence of increased work done by the muscles of our rats after the daily administration of adrenalin.
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