Introduction of Iodized Oil into Respiratory Tract of Dog.

Abstract

While the introduction of substances opaque to the X-ray was begun as early as 1905 it was not until the work of Sicard and Forrestier 1 in 1921 that the practice became general. They used a chemical combination of iodine and poppy-seed oil which is called lipiodol. This is now in general use in diagnosis and in limited use in therapy. Our immediate interest was whether it injured a normal healthy lung.

During the past 2 years we gave dogs repeated doses of lipiodol. During the year 1926-27 most of the work was done by M. I. Smedal and P. A. Duehr.

In one group the dogs were given 2 cc. per kilo body weight and repeated when their urine became iodine free. This period varied from 23 to 67 days. The first 4 dogs belong to this group. In the remaining dogs the treatment was empirical as is often the case in the clinic. Five small dogs averaging about 8 kilos were selected and the oil introduced at convenient periods.

In both groups the several methods of administering the oil were used. Errors as well as hits are recorded so that one may have an idea of how much oil each dog received.

No. 1 received 10 cc. in the right lung Jan. 1; 10 cc. in the pretracheal fascia Feb. 17; autopsied April 26.

No. 2 received 10 cc. in both lungs Feb. 26; 10 cc. in the stomach March 26; 10 cc. in both lungs April 2; autopsied May 3.

No. 3 received 7 cc. in both lungs Feb. 17—most of this was soon coughed up and swallowed; 7 cc. in both lungs Feb. 26; 12 cc. in both lungs April 23; autopsied May 4.