Abstract
In a previous report 1 it was stated that typical ovario-testis could be produced in adult male rats by grafting the ovaries of immature females into the testis, subsequently giving daily transplants of the anterior lobe, using Smith's technique. 2
Eight to 12 days of treatment is sufficient to produce numerous ovarian follicles of mature condition in the ovarian graft, but no changes have been observed in the host animal. If the daily transplants are continued for 18 days, the ovarian mass engrafted in the testis is greatly increased. The large follicles are more numerous, and in many cases, the thecal cells have hypertrophied, forming a layer of lutein cells around the periphery of the follicle.
As shown in Fig. 2, the response in the tissue of the mammary gland of the treated male rat bearing an ovarian graft is markedly different from that of its litter-mate (Fig. 1), which had received the same number of daily transplants of anterior lobe, but which did not bear an ovarian graft.
These rats possess normal seminiferous tubules, and have mated with normal females during the experimental period. All animals bearing grafts have sired 1 litter, many 2 litters, and a few 3 litters, during the period of the experiment.
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