Abstract
Summary
Virulent bacteria put in the nares of rabbits soon appear in the general circulation and produce septicemic infections. Less virulent bacteria also appear in the blood but may not cause infection. Killed bacteria put into the nares stimulate systemic antibody production. Bacteria occurring in the nasal passages in the carrier state stimulate a very rapid antibody response. These observations indicate that the mucous membrane of the upper air passages is reactly permeated by bacteria and their products.
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