Abstract
A previous publication 1 gave a comparison between the distribution of arsenic after intravenous injection of arsenicals in normal animals 2 and in animals under the influence of epinephrin. When the involuntary nervous system is under the influence of epinephrin, almost 5 times as much arsenic is retained in the blood stream and only a small part of the arsenic normally distributed to the brain and liver reaches those organs. The general aspect of these tests led to the assumption that epinephrin inhibits the normal distribution of arsenic into the body organs.
In a second series of tests, 2 groups of rats were given subcutaneous injections of pilocarpin previous to the intravenous injections of salvarsan, neosalvarsan and silversalvarsan. 160 mg. of salvarsan per kg. body weight was the dosage used for the normal rats and the pilocarpinized rats were given 80 mg. per kg. body weight. The figures for neosalvarsan and silversalvarsan are similar to those 
reported for salvarsan and will be given in detail in a later paper. The rats receiving pilocarpin were divided into two groups. One group received one injection of 5 mg. of pilocarpin 1 hour before the injection of the arsenical while, in the other group, four doses of 5 mg. each of pilocarpin were given 72, 48, 24 and 1 hour before the intravenous injections of the same arsenical preparations. The results for the two groups, as shown in the chart below do not differ greatly. Minor differences will be discussed in a later publication.
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