Abstract
In an attempt to study the effect on the kidney of the presence of large amounts of normal urinary constituents in the blood, we transplanted the ureters into different portions of the intestine. A simplified surgical technic was employed and the results were for the most part satisfactory. In most instances the only demonstrable change in the ureter and kidney was slight dilatation of the ureter and pelvis of the kidney, while microscopic examination of the renal tissue revealed but minor changes. In some cases, however, hydroureter and hydronephrosis with subsequent pyonephrosis developed. These cases furnished an interesting comparison to uncomplicated ureteral transplantation.
A single ureter was transplanted into the jejunum, ileum, colon, and rectum in different dogs. When the other kidney and ureter was not disturbed practically no change was observed in the nitrogenous constituents of the blood over a period of several weeks following operation. Bilateral transplantation of the ureters or single transplantation with removal of the kidney on the opposite side produced some very interesting changes in the constituents of the blood. Drainage of the ureters into the rectum produced in most instances a marked rise in the blood urea for from several days to six weeks after operation and a subsequent return of the level of urea in the blood to a figure which is within normal limits. No changes were found in the creatinine, creatine, uric acid, or ammo-acid content of the blood. Following ureteral transplantation into the colon there was a similar rise in the blood urea nitrogen without significant changes in the other nitrogenous blood constituents studied.
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